Réaction #339170

Équation de réaction

2-amino-5-chloro-3-methylbenzoic acid

4-bromo-1-(3-cyano-2-pyridinyl)-1H-pyrrole-2-carboxylic acid

2-amino-3,5-dibromobenzoic acid

4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid

→

6,8-dibromo-2-[4-bromo-1-(3-cyano-2-pyridinyl)-1H-pyrrol-2-yl]-4H-3,1-benzoxazine-4-one

Conditions de réaction

Mode opératoire

According to the same manner as that of Reference Preparation Example 71-(5), 4-bromo-1-(3-cyano-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 2-amino-3,5-dibromobenzoic acid were used in place of 4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 2-amino-5-chloro-3-methylbenzoic acid respectively to obtain 6,8-dibromo-2-[4-bromo-1-(3-cyano-2-pyridinyl)-1H-pyrrol-2-yl]-4H-3,1-benzoxazine-4-one of the formula:

Source