Réaction #339106

Équation de réaction

2-amino-5-chloro-3-methylbenzoic acid

triphosgene

→

6-chloro-8-methyl-1H-benzo[d]-1,3-oxazine-2,4-dione

Rendement 187.0%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   ConcentrationThe reaction mixture was concentrated under reduced pressure
2. 2
   Lavagea precipitated crystal was washed with water

Mode opératoire

A mixture of 1.85 g of 2-amino-5-chloro-3-methylbenzoic acid, 0.90 g of triphosgene and 10 ml of tetrahydrofuran was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and a precipitated crystal was washed with water to obtain 1.20 g of 6-chloro-8-methyl-1H-benzo[d]-1,3-oxazine-2,4-dione of the formula:

Source