Réaction #3364

ord-c22db2c5c35e41f08e3017072fa1182e

Équation de réaction

CC(C)CC(NC(=O)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)O)C(C)C)C(=O)O
2-[2-[2-(1-carboxy-3-methylbutyl carbamoyl)phenyldisulfanyl]benzoylamino]-3-methylbutanoic acid
BrBr
bromine
→
CC(C)C(C(=O)O)n1sc2ccccc2c1=O
title compound
Rendement 0.1%
CC(C)C(C(=O)O)n1sc2ccccc2c1=O
3-Methyl-2-(3-oxo-3h-benzo[d]isothiazol-2-yl)-butanoic acid
Rendement 0.1%

Réactifs

CC(C)CC(NC(=O)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)O)C(C)C)C(=O)O
2-[2-[2-(1-carboxy-3-methylbutyl carbamoyl)phenyldisulfanyl]benzoylamino]-3-methylbutanoic acid
BrBr
bromine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Following the procedure of Example 13, 6.0 g (13.6 mol) of 2-[2-[2-(1-carboxy-3-methylbutyl carbamoyl)phenyldisulfanyl]benzoylamino]-3-methylbutanoic acid was reacted with bromine to provide 2.25 g of the title compound, mp 166°-168° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05733921uspto-grants-1998_03