Réaction #3356

ord-93e8df1342c5499d9b84345b5640a0a8

Équation de réaction

CC(C)[C@H](N)C(=O)O
valine
O=C(Cl)c1ccccc1SSc1ccccc1C(=O)Cl
2,2'-dithiobisbenzoyl chloride
→
CC(C)C(NC(=O)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)O)C(C)C)C(=O)O
title compound
CC(C)C(NC(=O)c1ccccc1SSc1ccccc1C(=O)NC(C(=O)O)C(C)C)C(=O)O
2-[2-[2-(1-Carboxy-2-methylpropylcarbamoyl) phenyldisulfanyl]benzoylamino]-3-methylbutanoic acid

Réactifs

CC(C)[C@H](N)C(=O)O
valine
O=C(Cl)c1ccccc1SSc1ccccc1C(=O)Cl
2,2'-dithiobisbenzoyl chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Using the method employed in Preparation 30, 17.8 g (0.15 mol) of D,L valine was reacted with 17.2 g (0.05 mol) of 2,2'-dithiobisbenzoyl chloride to produce 11.4 g of the title compound after recrystallization from acetic acid, mp 226.5°-227.5° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05733921uspto-grants-1998_03