Réaction #334821

Équation de réaction

mannitol

acetone

→

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol

Conditions de réaction

Traitement

1. 1
   Concentrationof concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask
2. 2
   Autrethe acetone is evaporated by vacuum distillation at about 30° C
3. 3
   workup.ADDITIONThe remaining yellowish oil is diluted with an equal volume of cold water in order
4. 4
   Autreto provide the crystalline product
5. 5
   FiltrationThe crystals are filtered
6. 6
   Autredried
7. 7
   Autreused without further purification

Mode opératoire

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol is prepared by rapidly stirring with a mechanical stirrer, of 40 g of mannitol and 500 ml of anhydrous acetone in the presence of 4.0 ml of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask. The sulfuric acid is neutralized with about 6.8 g anhydrous sodium carbonate and the acetone is evaporated by vacuum distillation at about 30° C. The remaining yellowish oil is diluted with an equal volume of cold water in order to provide the crystalline product. The crystals are filtered, dried, and used without further purification.

Source