Réaction #3315

Équation de réaction

ethylamine

4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester

triethylamine

→

4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester

Rendement 90.0%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated in vacuo
2. 2
   Autrepartitioned between chloroform and saturated aqueous sodium bicarbonate
3. 3
   SéchageThe organic layer was dried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated

Mode opératoire

To a room temperature solution of 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester (10.00 g, 43.10 mmol) in 150 mL of tetrahydrofuran was added triethylamine (18.5 mL, 133 mmol) followed by 9 mL of a 70% aqueous solution of ethylamine. The solution was stirred for 30 minutes, then concentrated in vacuo and partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to provide 9.32 g (90%) of 4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester as an oil.

Source