Réaction #330741

Équation de réaction

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one

phosphoryl trichloride

→

3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine

Conditions de réaction

Traitement

1. 1
   Températurecooled to room temperature
2. 2
   workup.ADDITIONpoured onto ice water
3. 3
   AutreThe formed precipitate is separated
4. 4
   Lavagewashed with water
5. 5
   Autredried

Mode opératoire

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one (500 mg) is added stepwise to phosphoryl trichloride (1.8 ml). The reaction mixture is heated to 100° C. for 1 hour, then cooled to room temperature and poured onto ice water. The formed precipitate is separated, washed with water and dried to give 3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine (509 mg).

Source