Réaction #324438

Équation de réaction

(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Et3N

methanesulfonyl chloride

→

3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Solvants

CH2Cl2

brine

Conditions de réaction

Traitement

1. 1
   Extractionthe mixture extracted with CH2Cl2 (2×)
2. 2
   AutreThe combined organics were dried

Mode opératoire

To (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (2.0 g, 10.9 mmol) in CH2Cl2 (50 mL) at 0° C. was added Et3N (1.4 g, 1.9 mL, 13.4 mmol) and methanesulfonyl chloride (1.38 g, 0.94 mL, 12.1 mmol). After 1 h, brine was added and the mixture extracted with CH2Cl2 (2×). The combined organics were dried to give 3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester that was used without further purification.

Source