Réaction #324377

Équation de réaction

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid

oxalyl dichloride

→

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Autrewhile elevating to room temperature
2. 2
   ConcentrationThe mixture was concentrated under reduced pressure

Mode opératoire

Under an argon atmosphere, to a solution of 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid (9) (1.07 g, 4.02 mmol) in CH2Cl2 (10 mL) was added DMF (3 drops) by a Pasteur pipette at room temperature. To this was added oxalyl dichloride (680 μL, 8.04 mmol) at 0° C. and the mixture was stirred for 30 minutes while elevating to room temperature. The mixture was concentrated under reduced pressure to give crude 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride (10) as a colorless oil, which was used in the following reaction without further purification.

Source