Réaction #324361

ord-cc18d6845501455995a9f42bb0d6eea0

Équation de réaction

Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1.O=C(O)C(O)C(O)C(=O)O
Tolterodine tartrate
→
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
Tolterodin

Réactifs

Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1.O=C(O)C(O)C(O)C(=O)O
Tolterodine tartrate
—
cellulose
—
ethylcellulose

Réactifs

Aucun

Solvants

O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreDry pellet cores
  2. 2
    workup.DISSOLUTIONWithin first hour almost 50% dissolves, however between 7 and 16 hours
  3. 3
    workup.DISSOLUTIONless dissolves

Mode opératoire

Tolterodine tartrate, microcrystalline cellulose and part of ethylcellulose are blended with small amount of water into homogeneous blend from which pellet cores are made by extrusion and spheronization. Dry pellet cores are coated with the coating dispersion of Example 8. Within first hour almost 50% dissolves, however between 7 and 16 hours less dissolves as compared to Example 2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08642078B2uspto-grants-2014_02