Réaction #323710

ord-bd8b79c959cb4cf496a746ede2158b54

Équation de réaction

Cc1cscc1S(=O)(=O)N=C=O
4-methyl-3-thiophenesulfonyl isocyanate
COc1cc(OC)nc(N)n1
2-amino-4,6-dimethoxypyrimidine
→
COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2cscc2C)n1
desired product
Rendement 43.3%
COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2cscc2C)n1
N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methyl-3-thiophenesulfonamide
Rendement 43.3%

Réactifs

Cc1cscc1S(=O)(=O)N=C=O
4-methyl-3-thiophenesulfonyl isocyanate
COc1cc(OC)nc(N)n1
2-amino-4,6-dimethoxypyrimidine

Réactifs

Aucun

Solvants

CC#N
acetonitrile
CC#N
acetonitrile

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    workup.STIRRINGThe mixture was stirred for 16 hours at ambient temperature
  2. 2
    Filtrationfiltered

Mode opératoire

A solution of 2 g of 4-methyl-3-thiophenesulfonyl isocyanate in 5 ml of dry acetonitrile was added to 1.5 g of 2-amino-4,6-dimethoxypyrimidine in 20 ml of acetonitrile with stirring. The mixture was stirred for 16 hours at ambient temperature and filtered to yield 1.5 g of the desired product, m.p. 175°-178°.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04645529uspto-grants-1987_02