Réaction #323010

Équation de réaction

2-amino-7-chloro-1,8-naphthyridine

2-fluorophenol

potassium hydroxide

→

2-Amino-7-(2-fluorophenoxy)-1,8-naphthyridine

Rendement 58.2%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   LavageAfter treatment with caustic soda and washing
2. 2
   Autrethe product produced (24 g; m.p. 202° C.)
3. 3
   workup.DISSOLUTIONis dissolved
4. 4
   Autrethe crystallised solid is separated by filtration
5. 5
   Lavagewashed with ethanol (2×15 cc)
6. 6
   Autredried at 40° C. under reduced pressure (0.067 kPa)

Mode opératoire

The procedure is similar to that described in Example 37, but starting with 2-amino-7-chloro-1,8-naphthyridine (18 g), 2-fluorophenol (44.8 g) and potassium hydroxide pellets (13.2 g; 85% purity). After treatment with caustic soda and washing, the product produced (24 g; m.p. 202° C.) is dissolved in boiling ethanol (200 cc). After 16 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×15 cc) and dried at 40° C. under reduced pressure (0.067 kPa). 2-Amino-7-(2-fluorophenoxy)-1,8-naphthyridine (14.9 g) is produced, m.p. 206° C.

Source