Réaction #323003

Équation de réaction

3-methoxybenzoic acid

2-amino-7-methoxy-1,8-naphthyridine

→

N-(7-methoxy-1,8-naphthyridin-2-yl)-3-methoxybenzamide

Rendement 70.4%

Solvants

water

acetonitrile

Conditions de réaction

Traitement

1. 1
   Autrethe crystallised solid is separated by filtration
2. 2
   Lavagewashed with acetonitrile (3×10 cc)
3. 3
   Autredried at 50° C. under reduced pressure (0.067 kPa)

Mode opératoire

The procedure is similar to that described in Example 1, but starting with 3-methoxybenzoic acid (9.1 g), N,N'-carbonyldiimidazole (9.7 g) and 2-amino-7-methoxy-1,8-naphthyridine (7 g). The product produced by precipitation in water (13 g; m.p. approximately 75° C.) is dissolved in 90 cc of boiling acetonitrile. After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (3×10 cc) and dried at 50° C. under reduced pressure (0.067 kPa). N-(7-methoxy-1,8-naphthyridin-2-yl)-3-methoxybenzamide (8.7 g) is produced, m.p. 135° C.).

Source