Réaction #322997

Équation de réaction

ethanol

2,6-difluorobenzoic acid

2-amino-7-methoxy-1,8-naphthyridine

→

N-(7-methoxy-1,8-naphthyridin-2-yl)-2,6-difluorobenzamide

Rendement 40.4%

Solvants

water

Conditions de réaction

Traitement

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   Autrethe crystallised solid is separated by filtration
3. 3
   Lavagewashed with ethanol (10 cc)
4. 4
   Autredried at 45° C. under reduced pressure (0.067 kPa)

Mode opératoire

The procedure is similar to that described in Example 1, but starting with 2,6-difluorobenzoic acid (5.1 g), N,N'-carbonyldiimidazole (5.2 g) and 2-amino-7-methoxy-1,8-naphthyridine (4.4 g). The product produced by precipitation in water (4.5 g; m.p. 215°-217° C.) is dissolved in boiling ethanol (70 cc). After 1 hour's cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (10 cc) and dried at 45° C. under reduced pressure (0.067 kPa). N-(7-methoxy-1,8-naphthyridin-2-yl)-2,6-difluorobenzamide (3.2 g) is produced, m.p. 219°-220° C.

Source