Réaction #322989

Équation de réaction

acetonitrile

benzoic acid

2-amino-7-methoxy-1,8naphthyridine

→

N-(7-methoxy-1,8-naphthyridin-2-yl)benzamide

Rendement 39.8%

Solvants

water

Conditions de réaction

Traitement

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   Autrethe crystallised solid is separated by filtration
3. 3
   Lavagewashed with acetonitrile (2×10 cc)
4. 4
   Autredried at 40° C. under reduced pressure (0.067 kPa)

Mode opératoire

The procedure is similar to that described in Example 1, but starting with benzoic acid (13.4 g), N,N'carbonyldiimidazole (17.8 g) and 2-amino-7-methoxy-1,8naphthyridine (12.3 g). The product produced by precipitation in water (20 g; m.p. 80° C.) is dissolved in boiling acetonitrile (200 cc). After 1 hour's cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (2×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-methoxy-1,8-naphthyridin-2-yl)benzamide (7.8 g) is produced, m.p. 134° C. EXAMPLE 10

Source