Réaction #321759

Équation de réaction

2-fluoro-4-acetoxybenzoic acid

phosphorus pentachloride

→

2-fluoro-4-acetoxy-benzoyl chloride

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling
2. 2
   workup.DISTILLATIONthe solvent of the reaction mixture was distilled off

Mode opératoire

Then, in a 100 ml-reaction vessel, 9.5 g (4.80×10-2M) of 2-fluoro-4-acetoxybenzoic acid and 50 ml of dry benzene were placed. To the mixture, 10.3 g (4.94×10-2M) of phosphorus pentachloride was added in 30 minutes at room temperature, followed by stirring for 4 hours at 50° C. After cooling, the solvent of the reaction mixture was distilled off to provide oily 2-fluoro-4-acetoxy-benzoyl chloride.

Source