Réaction #321352

Équation de réaction

NaHCO3

iodoacetyl chloride

5-Aminosalicylamide

HCl

→

5-(iodoacetamido)salicylamide

Rendement 101.2%

Solvants

water

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONis added dropwise over 15 min
2. 2
   AutreThe precipitate is collected
3. 3
   Séchagedried in vacuo over NaOH pellets

Mode opératoire

To an ice-cooled, stirred solution of 5-Aminosalicylamide (10.0 grams, 0.073 tool), in 300 mL of water containing NaHCO3 (42.0 grams, 0.5 tool), iodoacetyl chloride (18.4 grams, 0.09 mol) is added dropwise over 15 min. After stirring at 0°-5° C. for 1 hr., the solution is acidified with cold 6N HCl. The precipitate is collected and dried in vacuo over NaOH pellets, to afford 21.3 grams (96% yield) of crude 5-(iodoacetamido)salicylamide.

Source