Réaction #317955

ord-1300b71d4d044fc9aa10397a27f3c6f6

Équation de réaction

Cl.ClCc1ccccn1
2-Chloromethylpyridine hydrochloride
COC(=O)c1cc2cc(O)ccc2[nH]1
methyl 5-hydroxy-1H-indole-2-carboxylate
COC(=O)c1cc2cc(OCc3ccccn3)ccc2[nH]1
compound
Rendement 18.1%
COC(=O)c1cc2cc(OCc3ccccn3)ccc2[nH]1
Methyl 5-(pyridin-2-ylmethoxy)-1H-indole-2-carboxylate
Rendement 18.1%

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

2-Chloromethylpyridine hydrochloride (515 mg) and methyl 5-hydroxy-1H-indole-2-carboxylate (600 mg) were processed in the same manner as in Production Example 1-1 to obtain the entitled compound (160 mg).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07566781B2uspto-grants-2009_07