Réaction #3150

Équation de réaction

water

sodium

p-fluoronitro benzene

2,2,2-trifluoro ethanol

→

p-(2,2,2-trifluoroethoxy) nitrobenzene

Rendement 62.0%

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas dropped
2. 2
   Températurerefluxed for 4 hours
3. 3
   Autreprecipitated solids
4. 4
   Lavagewere washed with water
5. 5
   Autredried

Mode opératoire

Under a nitrogen atmosphere, 10.1 g (0.44 mol) of sodium was dissolved in 200 ml of 2,2,2-trifluoro ethanol in 300 ml of a three-necked flask, to which 40 ml (0.38 mol) of p-fluoronitro benzene was dropped and refluxed for 4 hours. After cooling to a room temperature, water was poured (about 1 liter), and precipitated solids were washed with water and dried, to obtain p-(2,2,2-trifluoroethoxy) nitrobenzene (yield: 62%; and melting point: 76.5° C.).

Source