Réaction #3142

Équation de réaction

4,6-dihydroxy-2-methylpyrimidinamine

sodium ethoxide

sodium

Acetamidine hydrochloride

diethyl malonate

→

4,6-dihydroxy-2-methylpyrimidine

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture heated

Mode opératoire

The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.

Source