Réaction #310431

Équation de réaction

stearylamine

benzoyl chloride

hydrogen chloride

→

crystals

Rendement 83.0%

N-stearylbenzamide

Rendement 83.0%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   AutreAn exothermic reaction
2. 2
   TempératureThe reaction mixture was heated to 100° C.
3. 3
   Autrewas terminated
4. 4
   TempératureThe reaction mixture was cooled, from which white crude crystals
5. 5
   Autrewere separated
6. 6
   Autrewere then recrystallized from alcohol
7. 7
   AutreThis recrystallization

Mode opératoire

27 g of stearylamine was dispersed in 100 ml of toluene. To this dispersion was added 13 g of benzoyl chloride at 70° C. An exothermic reaction occurred and the temperature of the mixture increased to 80° C. The reaction mixture was heated to 100° C. and that temperature was maintained for about 20 hours until generation of hydrogen chloride gas was terminated. The reaction mixture was cooled, from which white crude crystals were separated. The thus obtained white crystals were neutralized with sodium hydroxide and were then recrystallized from alcohol. This recrystallization gave white crystals melting at 85° C. to 87° C. The yield was 83%.

Source