Réaction #309041

ord-3df769860f44417bb3f955adb3f7aa03

Équation de réaction

CC(C)(C)c1cc(N)n(-c2ccc([N+](=O)[O-])cc2)n1
5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine
N#Cc1ccc(NN)cc1
4-cyanophenylhydrazine
→
CC(C)(C)c1cc(N)n(-c2ccc(C#N)cc2)n1
title compound
Rendement 85.0%
CC(C)(C)c1cc(N)n(-c2ccc(C#N)cc2)n1
4-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzonitrile
Rendement 85.0%

Réactifs

CC(C)(C)c1cc(N)n(-c2ccc([N+](=O)[O-])cc2)n1
5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine
N#Cc1ccc(NN)cc1
4-cyanophenylhydrazine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared (85% yield) in the same manner as described for 5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine, replacing 4-nitrophenylhydrazine with 4-cyanophenylhydrazine. MS LC-MS [M+H]+=241, RT=2.39 min.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08207166B2uspto-grants-2012_06