Réaction #308536

ord-b95799cb3e1c409391bc060b5b56035b

Équation de réaction

CC(=O)c1ccncc1
4-acetylpyridine
CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1
4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CCC(CC(=O)CC(=O)c2ccncc2)CC1
title compound
CC(C)(C)OC(=O)N1CCC(CC(=O)CC(=O)c2ccncc2)CC1
4-(2,4-Dioxo-4-pyridin-4-ylbutyl)piperidine-1-carboxylic acid tert-butyl ester

Réactifs

CC(=O)c1ccncc1
4-acetylpyridine
CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1
4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autredescribed in Preparation 22

Mode opératoire

Condensation of 4-acetylpyridine with 4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester, utilising the protocol described in Preparation 22, afforded the title compound: m/z (ES+)=247.2 [M-Boc+H]+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08207147B2uspto-grants-2012_06