Réaction #303956

Équation de réaction

2-((8-bromo-2-(3-fluorophenyl)quinolin-3-yl)methyl)isoindoline-1,3-dione

BINAP

morpholine

NH2NH2

→

(2-(3-fluorophenyl)-8-morpholinoquinolin-3-yl)-methanamine

Solvants

dioxane

EtOH

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONa mixture of starting material and product
2. 2
   workup.ADDITIONTo the reaction was added the reactants again
3. 3
   TempératureThe reaction was further heated for 2 h
4. 4
   Autrebefore partitioned between water and EtOAc
5. 5
   ExtractionThe water layer was extracted once with EtOAc
6. 6
   Extractionextracted with DCM (5 mL×3)
7. 7
   AutreRemoval of solvent
8. 8
   Autregave a foam, which
9. 9
   Températureat reflux
10. 10
    AutreSolvents were removed
11. 11
    Autrepurified by CombiFlash® (DCM/MeOH/Et3N, 20/1/0.1)

Mode opératoire

A mixture of 2-((8-bromo-2-(3-fluorophenyl)quinolin-3-yl)methyl)isoindoline-1,3-dione (100 mg, 0.22 mmol), racemic BINAP (16.2 mg, 0.12 eq), Pd2(dba)3 (10 mg, 0.05 eq), NaOBut (29.2 mg, 1.4 eq) and morpholine (38 mg, 2 eq) in dioxane (2 mL) was heated to 120° C. under N2 for 8 h. LCMS showed a mixture of starting material and product. To the reaction was added the reactants again. The reaction was further heated for 2 h before partitioned between water and EtOAc. The water layer was extracted once with EtOAc and acidified to pH 2 by 3 N HCl and extracted with DCM (5 mL×3). Removal of solvent gave a foam, which was treated with NH2NH2 (0.5 mL) in EtOH (2 mL) at reflux. Solvents were removed and the residue was worked up and purified by CombiFlash® (DCM/MeOH/Et3N, 20/1/0.1). A white solid was obtained as (2-(3-fluorophenyl)-8-morpholinoquinolin-3-yl)-methanamine. N-((2-(3-fluorophenyl)-8-morpholinoquinolin-3-yl)methyl)-9H-purin-6-amine was prepared according to Procedures H. 1H-NMR (400 Hz, CD3OD) δ 8.77 (s, 1H), 8.54 (s, 1H), 8.50 (s, 1H), 8.25 (d, J=8.0 Hz, 2H), 7.85 (t, J=8.0 Hz, 1H), 7.61-7.54 (m, 3H), 7.24 (t, J=8.0 Hz, 1H), 5.24 (s, 2H), 4.20 (s, 4H), 4.02 (s, 4H). Mass Spectrum (ESI) m/e=456 (M+1).

Source