Réaction #302882

Équation de réaction

1,5-Dichloroanthraquinone

3-amino-1-propanol

water

→

1,5-Bis(3-hydroxypropylamino)-anthraquinone

Solvants

DMSO

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture is cooled to ˜80°
2. 2
   Autrehas reached RT
3. 3
   Autreis isolated by filtration
4. 4
   Lavagewashed with water (2×50 mL)
5. 5
   Autrethe un-dissolved product is isolated by filtration
6. 6
   Autredried

Mode opératoire

1,5-Dichloroanthraquinone (2.8 g; 10 mmol) is mixed with 3-amino-1-propanol (10 mL) in DMSO (50 mL) and heated to 130° C. for 4 hours. The mixture is cooled to ˜80° and added water (150 mL). When the mixture has reached RT the formed precipitate is isolated by filtration, washed with water (2×50 mL), boiled in toluene (200 mL) and the un-dissolved product is isolated by filtration and dried. Yield: 3.2 g (90%).

Source