Réaction #302857

Équation de réaction

5′-methoxy-2′-hydroxyacetophenone

4-nitrobenzoyl chloride

hydrochloric acid

→

compound 21

4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   AutreThe obtained mixture was reacted at room temperature for 30 minutes
2. 2
   Températureunder cooling on ice
3. 3
   FiltrationThe obtained precipitate was collected by filtration
4. 4
   Lavagethe filtrate was then washed with purified water

Mode opératoire

5′-methoxy-2′-hydroxyacetophenone (1.5 g, 9.03 mmol) was added to a pyridine solution (20 ml) that contained 4-nitrobenzoyl chloride (1.72 g, 9.26 mmol) in an ice bath. The obtained mixture was reacted at room temperature for 30 minutes, and the reaction solution was then poured into 1 N hydrochloric acid under cooling on ice. The obtained mixture was intensively stirred. The obtained precipitate was collected by filtration, and the filtrate was then washed with purified water, so as to obtain a product of interest, 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (compound 21). Yield: 2.49 g (yield constant: 87.4%)

Source