Réaction #2945

ord-fc50405695d1443a80eda06a3dd99d45

Équation de réaction

C=C1CC(=O)O1.CC(C)=O
diketene acetone
C1CCNC1
pyrrolidine
→
CC(=O)CC(=O)N1CCCC1
title compound
Rendement 97.9%
CC(=O)CC(=O)N1CCCC1
1-(3-Oxobutyryl)pyrrolidine
Rendement 97.9%

Réactifs

C=C1CC(=O)O1.CC(C)=O
diketene acetone
C1CCNC1
pyrrolidine

Réactifs

Aucun

Solvants

Cc1ccccc1
toluene

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autreas described in preparation 7
  2. 2
    AutreThe solvent was removed in vacuo
  3. 3
    Autrethe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

Mode opératoire

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05731322uspto-grants-1998_03