Réaction #2894

Équation de réaction

n-Butyllithium

4-methylthiazole

trimethylsilylchloride

→

title compound

4-Methyl-2-trimethylsilylthiazole

Solvants

diethyl ether

Conditions de réaction

Traitement

1. 1
   Autrewas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
2. 2
   workup.DISTILLATIONWork-up in the normal fashion and vacuum distillation

Mode opératoire

n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.

Source