Réaction #2808

Équation de réaction

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

pyridine

2-(trimethylsilyl)ethanol

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

→

title compound

Rendement 81.0%

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid, 2-trimethylsilanyl-ethyl ester

Rendement 81.0%

Solvants

ethyl acetate

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Températurecool in an ice bath
2. 2
   workup.STIRRINGStir for 22 hours at 5° C.
3. 3
   workup.WAITat room temperature for 1.5 hours
4. 4
   workup.ADDITIONadd 0.6 times all reagents
5. 5
   workup.STIRRINGstir at room temperature overnight
6. 6
   Lavagewash with 5% sulfuric acid (40 mL) and saturated sodium hydrogen carbonate (40 mL)
7. 7
   ExtractionBack extract with methylene chloride (100 mL)
8. 8
   Lavagewash with brine (30 mL)
9. 9
   Séchagedry (Na2SO4)
10. 10
    AutreEvaporate the solvent in vacuo
11. 11
    Autrepurify by silica gel chromatography (2:1 hexane/ethyl acetate)

Mode opératoire

Dissolve 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid (2.47 g, 7.69 mmol) in tetrahydrofuran (35 mL) and cool in an ice bath. Treat with pyridine (1.6 mL, 20 mmol) and 2-(trimethylsilyl)ethanol (2.3 mL, 16 mmol). Stir for 30 minutes and add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (2.21 g, 11.5 mmol). Stir for 22 hours at 5° C., then at room temperature for 1.5 hours. Cool to 0° C., add 0.6 times all reagents and stir at room temperature overnight. Dilute with ethyl acetate (150 mL), wash with 5% sulfuric acid (40 mL) and saturated sodium hydrogen carbonate (40 mL). Back extract with methylene chloride (100 mL), wash with brine (30 mL) and dry (Na2SO4). Evaporate the solvent in vacuo and purify by silica gel chromatography (2:1 hexane/ethyl acetate) to give the title compound (2.61 g, 81%).

Source