Réaction #2622

ord-a5a1347378234e5ea5c192cce8e4d5a5

Équation de réaction

COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(NC(C)=O)cc2)c1

4-acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide

$O=C(O)/C=C\C(=O)O$

maleic acid

→

$COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(NC(C)=O)cc2)c1.O=C(O)/C=C\C(=O)O$

title compound

Rendement 86.3%

$COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(NC(C)=O)cc2)c1.O=C(O)/C=C\C(=O)O$

4-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide maleate

Rendement 86.3%

Réactifs

4-acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide

$O=C(O)/C=C\C(=O)O$

maleic acid

Réactifs

Aucun

Conditions de réaction

Conditions détaillées

See reaction.notes.procedure_details.

Mode opératoire

Using 4-acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (155.0 mg, 0.30 mmol) and maleic acid (45.0 mg, 0.30 mmol), the procedure of Inventive Example 211 was repeated to obtain 164.0 mg (82.0%) of the title compound in a colorless powder form.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05728835uspto-grants-1998_03