Réaction #2556

Équation de réaction

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

Rendement 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

Rendement 25.0%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   TempératureAfter 12 hours of heating
2. 2
   Températureunder reflux
3. 3
   Autrethe solvent was removed by evaporation
4. 4
   Autrethe resulting residue was purified

Mode opératoire

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

Source