Réaction #2555

Équation de réaction

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride

sodium carbonate

→

title compound

Rendement 92.3%

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine

Rendement 92.3%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   TempératureWith cooling in an ice bath
2. 2
   ExtractionThe reaction solution was extracted with ether
3. 3
   Lavagewashed with saturated brine
4. 4
   Séchagethe resulting organic layer was dried on anhydrous sodium carbonate
5. 5
   FiltrationThereafter, the organic layer was filtered through silica gel (5 g)
6. 6
   Autrethe solvent was removed by evaporation
7. 7
   Autrethe resulting residue was purified

Mode opératoire

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride (800 mg, 2.61 mmol) was suspended in ether (20 ml). With cooling in an ice bath, saturated sodium carbonate aqueous solution (5 ml) was added dropwise to the suspension. The reaction solution was extracted with ether and washed with saturated brine, and the resulting organic layer was dried on anhydrous sodium carbonate. Thereafter, the organic layer was filtered through silica gel (5 g), the solvent was removed by evaporation and then the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 650 mg (92.3%) of the title compound in the form of light yellow solid.

Source