Réaction #2507848

Équation de réaction

3-t-Butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole

tetrabutylammonium fluoride tetrahydrofuran

→

desired compound

Rendement 46.4%

1,2-dihydro-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)-3H-pyrazol-3-one

Rendement 46.4%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   ConcentrationThe reaction solution was concentrated
2. 2
   Autrethe residue was purified on a silica gel column chromatography (ethyl acetate-hexane=1:4)

Mode opératoire

3-t-Butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole (1.95 g; 4.22 mmol) was dissolved in tetrahydrofuran (30 ml) and cooled to 0° C. A 1 M tetrabutylammonium fluoride-tetrahydrofuran solution (6.33 ml; 6.33 mmol) was gradually added, then the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated, and the residue was purified on a silica gel column chromatography (ethyl acetate-hexane=1:4) to give the desired compound (684 mg; 1.96 mmol). (46%)

Source