Réaction #2481500

Équation de réaction

Hydrogen chloride

N2 tert-butoxycarbonyl-N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide

→

desired product

Rendement 100.0%

N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide hydrochloride

Rendement 100.0%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   AutreAfter the completion of the reaction
2. 2
   Autrethe methylene chloride was removed under reduced pressure
3. 3
   Autrethus yielding a crude crystal
4. 4
   LavageThe crude crystal was washed with acetone

Mode opératoire

Hydrogen chloride gas was introduced into a solution containing 3.7 g of N2 -tert-butoxycarbonyl-N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide dissolved in 100 ml of methylene chloride for 1 hour at room temperature. After the completion of the reaction, the methylene chloride was removed under reduced pressure, thus yielding a crude crystal. The crude crystal was washed with acetone to afford 3.1 g of the desired product (yield: 100%).

Source