Réaction #2471383

Équation de réaction

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester

→

pure acid

Rendement 84.8%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-yl-methyl]-pyrrolidine-2(R)-carboxylic acid

Rendement 84.8%

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   Autreto degas the mixture
2. 2
   Autre(36 h)
3. 3
   FiltrationAfter filtering
4. 4
   Concentrationconcentration

Mode opératoire

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester (50 mg, 0.095 mmol) was combined with palladium on carbon (25 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (36 h). After filtering and concentration, 35 mg (84%) pure acid was obtained by trituration.

Source