Réaction #2471338

ord-cc3ce20c828c48bba3ed9892f3dc4365

Équation de réaction

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCC(C(F)(F)F)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(4-trifluoromethyl-cyclohexyl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCC(C(F)(F)F)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(4-trifluoromethyl-cyclohexyl)-urea
COC(=O)CS
methyl thioglycolate
→
COC(=O)CSc1cnc(NC(=O)N(C2CCCCC2)C2CCC(C(F)(F)F)CC2)s1
{2-[3-Cyclohexyl-3-(4-trifluoromethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid methyl ester

Réactifs

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCC(C(F)(F)F)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(4-trifluoromethyl-cyclohexyl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCC(C(F)(F)F)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(4-trifluoromethyl-cyclohexyl)-urea
COC(=O)CS
methyl thioglycolate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePrepared

Mode opératoire

Prepared as described in general procedure (D) using 3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(4-trifluoromethyl-cyclohexyl)-urea (Example 204) and methyl thioglycolate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08263634B2uspto-grants-2012_09