Réaction #2467938

Équation de réaction

4b

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid

MeOH

thionylchloride

→

desired product

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid methyl ester

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was heated
2. 2
   Températureto reflux
3. 3
   Concentrationconcentrated

Mode opératoire

To a suspension of 4b (0.1 mmol, 34 mg) in MeOH (2 mL), was added dropwise thionylchloride (22 μL, 0.3 mmol) at −30° C. Then, the solution was allowed to warm at room temperature. The reaction mixture was heated to reflux and concentrated to afford the desired product. The crude is purified by silica gel chromatography (EtOAc/MeOH 10/1) to give the pure compound as a yellow solid (11 mg, 32%).

Source