Réaction #2467048

Équation de réaction

sodium bicarbonate

diaminomethylenethiourea

Bromine

2-acetyl-6-cyanomethylpyridine

chloride

→

4-(6-cyanomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

Rendement 46.5%

Solvants

methanol

dioxane

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe mixture was stirred for 1 hour at 50° C
2. 2
   workup.STIRRINGthe mixture was stirred for 2.5 hours at 50° C
3. 3
   AutreThe solvent was removed by concentration in vacuo
4. 4
   workup.ADDITIONTo the residue was added
5. 5
   workup.ADDITIONa mixture of water, tetrahydrofuran and ethyl acetate
6. 6
   LavageThe separated organic layer was washed with brine
7. 7
   Séchagedried over magnesium sulfate
8. 8
   Autreevaporated in vacuo
9. 9
   AutreThe residue was triturated with water

Mode opératoire

Bromine (0.64 ml) was added to a mixture of 2-acetyl-6-cyanomethylpyridine (2.0 g) in dioxane (30 ml) and 4N-dioxanichydrogen chloride (3.1 ml) at ambient temperature with stirring, and then the mixture was stirred for 1 hour at 50° C. To the mixture was added the sodium bicarbonate (5.2 g), methanol (30 ml) and diaminomethylenethiourea (2.2 g) at ambient temperature and the mixture was stirred for 2.5 hours at 50° C. The solvent was removed by concentration in vacuo. To the residue was added a mixture of water, tetrahydrofuran and ethyl acetate and the mixture was adjusted to pH 9.5 with potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with water to give 4-(6-cyanomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (1.5 g).

Source