Réaction #2467018

ord-a95a7dab38524d37870975116e2bb7f8

Équation de réaction

CC(=O)NCc1ncc(C(=O)CBr)s1
2-acetylaminomethyl-5-bromoacetylthiazole
NC(=S)N=C(N)N
diaminomethylenethiourea
→
Br.Br.CC(=O)NCc1ncc(-c2csc(N=C(N)N)n2)s1
4-(2-acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide
Rendement 42.4%

Réactifs

CC(=O)NCc1ncc(C(=O)CBr)s1
2-acetylaminomethyl-5-bromoacetylthiazole
NC(=S)N=C(N)N
diaminomethylenethiourea

Réactifs

Aucun

Solvants

CC(C)=O
acetone

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Températurewas refluxed for 10 hours
  2. 2
    FiltrationThe resulting precipitate was collected by filtration

Mode opératoire

A mixture of 2-acetylaminomethyl-5-bromoacetylthiazole (6.30 g) and diaminomethylenethiourea [(H2N)2C=NCSNH2 ] (1.77 g) in acetone (90 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected by filtration to give 4-(2-acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide (2.21 g).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05364871uspto-grants-1994_11