Réaction #2467014

Équation de réaction

2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide

diaminomethylenethiourea

→

4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

Rendement 42.4%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 10 hours
2. 2
   AutreThe resulting precipitate was collected
3. 3
   workup.DISSOLUTIONdissolved in water (50 ml)
4. 4
   AutreThe separated product was collected
5. 5
   Lavagewashed with water

Mode opératoire

A mixture of 2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

Source