Réaction #2461604

Équation de réaction

4-chloro-7-(2-chloroethoxy)6-methoxyquinazoline

4-amino-5-chloro-2,3-methylenedioxypyridine

→

title compound

Rendement 92.0%

7-(2-chloroethoxy)-4-(5-chloro-2,3-methylenedioxypyrid-4-ylamino)-6-methoxyquinazoline

Rendement 92.0%

Conditions de réaction

Mode opératoire

Using an analogous procedure to that described in Example 1, 4-chloro-7-(2-chloroethoxy)6-methoxyquinazoline was reacted with 4-amino-5-chloro-2,3-methylenedioxypyridine to give the title compound in 92% yield; NMR Spectrum: (DMSOd6 and CD3CO2D) 4.05 (s, 3H), 4.1 (t, 2H), 4.55 (t, 2H), 6.3 (s, 2H), 7.4 (s, 1H), 7.9 (s, 1H), 8.15 (s, 1H), 8.95 (s, 1H); Mass Spectrum: M+H+ 409 and 411.

Source