Réaction #2453

Équation de réaction

2-fluoro-4-hydroxybenzoic acid

acetic anhydride

→

4-acetoxy-2-fluorobenzoic acid

Solvants

water

water

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONmixed
2. 2
   workup.ADDITIONwas added
3. 3
   Autreprecipitated crystal
4. 4
   Filtrationwas recovered by filtration
5. 5
   AutreThe crystal was dried under vacuum

Mode opératoire

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid was added. After the heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and precipitated crystal was recovered by filtration. The crystal was dried under vacuum and used in a subsequent step. The yield of the crystal was 4.7 g.

Source