Réaction #2389075

Équation de réaction

nabumetone

2-acetyl-5-bromo-6-methoxynaphthalene

→

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

Conditions de réaction

Traitement

1. 1
   AutreNew process for the synthesis of the antiinflammatory drug

Mode opératoire

New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.

Source