Réaction #2358549

Équation de réaction

compound ( 4 )

5-(2-(benzyloxy)-5-isopropyl-4-(methoxymethoxy)phenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol

HCl

→

5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride

Rendement 74.0%

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   Températurecooled
2. 2
   AutreThe white precipitate thus obtained
3. 3
   Filtrationwas filtered
4. 4
   Lavagewashed with ether (2×20 ml)

Mode opératoire

To the solution of compound (4) (2.10 g, 3.95 mmol) in MeOH (100 ml), HCl (2 ml, 2N) was added, and then the resultant mixture was heated at 65° C. for 5 h, then cooled. The white precipitate thus obtained was filtered, washed with ether (2×20 ml) gave 1.53 g (74%) of 5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride (5).

Source