Réaction #2358525

Équation de réaction

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

Rendement 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

Rendement 78.6%

Solvants

EtOH

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate (2×100 ml)
2. 2
   LavageThe combined organic phase was washed with brine (75 ml)
3. 3
   Séchagedried (Na2SO4)
4. 4
   Autreevaporated

Mode opératoire

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

Source