Réaction #2358499

Équation de réaction

methylphenidate HCl

→

Methylphenidate

Solvants

water

Conditions de réaction

Traitement

1. 1
   AutreThe wet pellets are dried (Fluid Air Model#0050)
2. 2
   Filtrationsieved (30 mesh<Acceptable<20 mesh)

Mode opératoire

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model#SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

Source