Réaction #2358487

Équation de réaction

2-fluoro-6-(trifluoromethyl)benzaldehyde

methyl thioglycolate

potassium carbonate

DMF

→

methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

Rendement 35.4%

Solvants

water

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was cooled to room temperature
2. 2
   Extractionextracted with tert-butyl methyl ether 3 times
3. 3
   LavageThe combined organic layer was washed with water
4. 4
   SéchageThe mixture was dried over magnesium sulfate
5. 5
   Concentrationconcentrated under reduced pressure

Mode opératoire

A mixture of 1.00 g of 2-fluoro-6-(trifluoromethyl)benzaldehyde, 633 mg of methyl thioglycolate, 1.21 g of potassium carbonate and 15 ml of DMF was stirred at 130° C. for 2 hours. The reaction mixture was cooled to room temperature. To the reaction mixture was added water, and then extracted with tert-butyl methyl ether 3 times. The combined organic layer was washed with water, followed by saturated aqueous sodium chloride solution. The mixture was dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 480 mg of methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (the present compound 3).

Source