Réaction #2345

Équation de réaction

compound

Methyl 2-t-butoxycarbonylamino-4-[4-[4-(4-pyridyl)-piperazin-1-yl]phenoxy]butyrat

→

title compound

Rendement 74.1%

Methyl 2-amino-4-[4-[4-(4-pyridyl) piperazin-1-yl]-phenoxy]butyrate

Rendement 74.1%

Solvants

TFA

Conditions de réaction

Traitement

1. 1
   AutreThe solution was evaporated
2. 2
   workup.DISSOLUTIONthe residue dissolved in water (15 ml)
3. 3
   ExtractionThe mixture was extracted three times with dichloromethane
4. 4
   AutreEvaporation of the combined extracts

Mode opératoire

The compound of Example 140 (0.96 g) in TFA (10 ml) was kept at room temperature for 2 hours. The solution was evaporated and the residue dissolved in water (15 ml) and the solution basified with sodium carbonate. The mixture was extracted three times with dichloromethane. Evaporation of the combined extracts gave the title compound (0.56 g); m.p. 125°-127° C.; NMR(d6DMSO) δ 8.2(2H,d), 6.92(6H,m), 4.0(2H,m), 3.64(3H,s), 3.46(4H,t), 3.15(4H,t), 2.04(2H,m), 1.84(1H, m); m/e 371(M+H)+. Calculated for C20H26N4 O3. 0.75 H2O: C, 62.5; H, 7.17; N, 14.6. Found: C, 62.8; H, 6.8; N, 14.3%.

Source