Réaction #2329005

ord-93f7bbd4bdcc4cb88643808d06832248

Équation de réaction

COc1ccc2nc(-c3ccc(F)nc3)oc2c1
5-(6-methoxy-1,3-benzoxazol-2-yl)-2-fluoropyridine
CN(C)c1ncc(C=O)cn1
2-dimethylamino-pyrimidine-5-carbaldehyde
COC(=O)c1ccc(N)c(O)c1
methyl 4-amino-3-hydroxybenzoate
COC(=O)c1ccc2nc(-c3cnc(N(C)C)nc3)oc2c1
title compound
Rendement 72.3%
COC(=O)c1ccc2nc(-c3cnc(N(C)C)nc3)oc2c1
Methyl 2-[2-(dimethylamino)pyrimidin-5-yl]-1,3-benzoxazole-6-carboxylate
Rendement 72.3%

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The synthesis was performed according to the procedure described for 5-(6-methoxy-1,3-benzoxazol-2-yl)-2-fluoropyridine starting with 180 mg of 2-dimethylamino-pyrimidine-5-carbaldehyde and 200 mg of methyl 4-amino-3-hydroxybenzoate to give 256.8 mg of the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07670591B2uspto-grants-2010_03