Réaction #2328980

Équation de réaction

water

2,5-Bis[(cyanoethyl)thio]-1,4-phenylenediamine

4-nitrobenzoyl chloride

→

title compound

Rendement 61.3%

2,5-bis[(2-cyanoethyl)sulfanyl]-N-(4-nitrobenzoyl)-1,4-phenylenediamine

Rendement 61.3%

Solvants

NMP

NMP

Conditions de réaction

Traitement

1. 1
   Autrepurge
2. 2
   workup.ADDITIONfollowed by addition of freshly distilled triethylamine (TEA) by syringe
3. 3
   workup.ADDITIONwas added into the stirred fed solution drop by drop over a period of 0.5 h
4. 4
   workup.STIRRINGwith stirring
5. 5
   FiltrationThe resultant yellow precipitate was collected by filtration
6. 6
   Lavageby washing with 800 mL of deionized water twice
7. 7
   ExtractionThe obtained product was extracted with methanol using a Soxhlet extractor for 24 h
8. 8
   AutreA yellow solution was collected
9. 9
   Autreevaporated
10. 10
    Autreby drying at 60° C. under vacuum overnight

Mode opératoire

2,5-Bis[(cyanoethyl)thio]-1,4-phenylenediamine (13.9 g, 50 mmol) was dissolved in 90 mL of NMP in a 250 mL 3-necked round-bottom flask under nitrogen purge. The resultant clear red solution was cooled to 0-5° C. in an ice bath, followed by addition of freshly distilled triethylamine (TEA) by syringe. After stirring for 10 minutes, a mixture of 4-nitrobenzoyl chloride (10.2 g, 55 mmol) and 90 mL of NMP was added into the stirred fed solution drop by drop over a period of 0.5 h. The resultant solution was stirred at 0-5° C. for 2 h and at room temperature for 1 h, followed by addition of 800 mL of water with stirring. The resultant yellow precipitate was collected by filtration, followed by washing with 800 mL of deionized water twice and 300 mL of methanol once. The obtained product was extracted with methanol using a Soxhlet extractor for 24 h. A yellow solution was collected and evaporated, followed by drying at 60° C. under vacuum overnight, giving the title compound as a red powder (13.1 g, yield 61%).

Source